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How do LUTS function and grow?

Poster Session 08

  • Location:
    Room Berlin, North Hall (Level 1)
  • Chairs:
     C. Gratzke, Munich (DE)
     R. Hamid, London (GB)
  • Aims and objectives of this session

    This session discusses the basic insights into LUT functioning.

  • Poster viewing of 20 minutes. Presentations will take place on stage. Standard presentations are 2 minutes in length, followed by 2 minutes for discussion.
103
Depletion of peripheral serotonin synthesis induces benign prostatic growth in mice: More evidence for the new neuroendocrine theory in BPH etiology

By: Mota P.M.1, Carvalho-Dias E.1, Miranda A.2, Martinho O.2, Nogueira-Silva C.3, Alenina N.4, Bader M.4, Autorino R.1, Lima E.1, Correia-Pinto J.5

Institutes: 1Surgical Sciences Research Domain, Life and Health Sciences Research Institute, ICVS/3B’s – PT Gover, Dept. of CUF Urology and Service of Urology – Hospital of Braga, Braga, Portugal, 2Life and Health Sciences Research Institute, ICVS/3B’s – PT Government Associate Laboratory, The Cli, Surgical Sciences Research Domain, Braga, Portugal, 3Surgical Sciences Research Domain, Life and Health Sciences Research Institute, ICVS/3B’s – PT Gover, Dept. of Obstetrics and Gynecology, Braga, Portugal, 4Max Delbrück Center For Molecular Medicine, Robert-Rössle-Str. 10, Berlin 13125, Germany, Berlin Institute of Health, Berlin, Germany, 5Surgical Sciences Research Domain, Life and Health Sciences Research Institute, ICVS/3B’s – PT Gover, Dept. of Pediatric Surgery – Hospital of Braga, Braga, Portugal

105
Impairment of autophagy is associated with obesity and inflammation in patients with benign prostatic hyperplasia and lower urinary tract symptoms

By: De Nunzio C.1, Giglio S.2, Cirombella R.2, Mallel G.2, Nacchia A.1, Lombardo R.1, Presicce F.1, Tubaro A.1, Vecchione A.2

Institutes: 1Sant’ Andrea Hospital – Sapienza University, Dept. of Urology, Rome, Italy, 2Sant’ Andrea Hospital – Sapienza University, Dept. of Molecular Pathology, Rome, Italy

106
Myogenic tone is significantly increased in benign prostatic hyperplasia and can be attenuated by sildenafil and tamsulosin, with outcome associated to patient age and prostate volume

By: Lee S.1, Chakrabarty B.2, Papargiris M.1, Ryan A.3, Frydenberg M.4, Lawrentschuk N.5, Middendorff R.6, Risbridger G.1, Ellem S.1, Exintaris B.7

Institutes: 1Monash University, Dept. of Anatomy and Developmental Biology, Clayton, Australia, 2Monash University, Drug Discovery Biology, Parkville, Australia, 3TissuePath, Dept. of Pathology, Melbourne, Australia, 4Monash University, Dept. of Surgery, Melbourne, Australia, 5Melbourne University, Dept. of Surgery, Melbourne, Australia, 6Justus-Liebig-University, Institute of Anatomy and Cell Biology, Giessen, Germany, 7Monash University, Dept. of Drug Discovery Biology, Parkville, Australia

107
Detection of Rac activity and inhibition of smooth muscle contraction by EHT1864 in the human trigone: Expanding the role of Rac GTPase in the lower urinay tract outflow region

By: Wang Y., Gratzke C., Rutz B., Yu Q., Strittmatter F., Herlemann A., Rutz B., Stief C., Hennenberg M.

Institutes: LMU Munich, Dept. of Urology, Munich, Germany

108
Inhibition of prostate smooth muscle contraction by the LIM kinase inhibitor, SR-7826: A new anticontractile strategy and implications for a role of LIM kinases in the control of prostate smooth muscle tone

By: Yu Q., Gratzke C., Wang Y., Rutz B., Herlemann A., Strittmatter F., Stief C., Hennenberg M.

Institutes: LMU-Klinikum der Universität München, Dept. of Urology, Munich, Germany

109
The anticontractile inhibitor, secinH3 inhibits ARF6, but not Rac or RhoA GTPase activities in the human prostate: A new role for ARF6 in smooth muscle contraction?

By: Hennenberg M., Wang Y., Herlemann A., Yu Q., Strittmatter F., Rutz B., Stief C., Gratzke C.

Institutes: LMU Munich, Dept. of Urology, Munich, Germany

110
The oxidants/antioxidants balance in patients with benign prostatic hyperplasia before and after the treatment with dutasteride

By: Ene C.V.1, Nicolae I.2, Ene C.D.3, Geavlete B.1, Geavlete P.1, Georgescu S.4

Institutes: 1St John Hospital Bucharest, Dept. of Urology, Bucharest, Romania, 2Clinical Hospital of Tropical and Infectious Diseases “Victor Babes”, Dept. of Research, Bucharest, Romania, 3Clinical Hospital of Nephrology “Carol Davila”, Dept. of Nephrology, Bucharest, Romania, 4Clinical Hospital of Tropical and Infectious Diseases “Victor Babes”, Dept. of Dermato-Venerology, Bucharest, Romania

111
Restraint stress induces nocturia in mice

By: Ihara T.1, Mitsui T.1, Nakamura Y.2, Imai Y.1, Kira S.1, Nakagomi H.1, Sawada N.1, Nakao A.2, Takeda M.1

Institutes: 1University of Yamanashi, Dept. of Urology, Yamanashi, Japan, 2University of Yamanashi, Dept. of Immunology, Yamanashi, Japan

112
The vitamin D analogue BXL-628 improves contraction development ex vivo in bladders of aged mice

By: Hohnen R.1, Rademakers K.2, Den Hartog G.3, Meriaux C.1, Van Koeveringe G.2

Institutes: 1Maastricht University, Dept. of Neuroscience, Maastricht, The Netherlands, 2Maastricht University Medical Center, Dept. of Urology, Maastricht, The Netherlands, 3Maastricht University, Dept. of Pharmacology and Toxicology, Maastricht, The Netherlands

113
Effects of litoxetine on urethral pressure and detrusor overactivity in anesthetized female rats

By: Méen M.1, Guérard M.1, Palea S.3, Gamé X.2, Lluel P.1

Institutes: 1Urosphere, Dept. of Pharmacology, Toulouse, France, 2CHU Rangueil, Dept. of Urology, Toulouse, France, 3Palea Pharma & Biotech Consulting, , Toulouse, France

114
Effects of the receptor antagonist picotamide on endothelin-1-, -2- and -3-induced contractions in human prostate smooth muscle

By: Hennenberg M., Tamalunas A., Strittmatter F., Stief C., Gratzke C.

Institutes: LMU Munich, Dept. of Urology, Munich, Germany

115
Two microRNA clusters may determine the biological functions of microRNA-regulated pathways in underactive bladder

By: Hashemi Gheinani A.1, Burkhard F.2, Monastyrskaya K.2

Institutes: 1Urology Research Laboratory, Dept. of Clinical Research, Bern, Switzerland, 2University Hospital Bern, Dept. of Urology, Bern, Switzerland

116
Detrusor bioengineering using compressed collagen, adipose-derived stem cells and smooth muscle cells

By: Smolar J.1, Horst M.2, Eberli D.1

Institutes: 1University Hospital Zurich, Dept. of Urology, Zürich, Switzerland, 2University Children’s Hospital, Dept. of Pediatric Urology, Zürich, Switzerland