Session

Upper urinary tract tumour: Outcomes after radical surgery & peri-operative chemotherapy

Poster Session 88

  • Location:
    Room Munich, North Hall (Level 1)
  • Chairs:
     S. Lerner, Houston (US)
     E. Xylinas, Paris (FR)
  • Aims and objectives of this session

    To date, radical surgery represents the only potentially curable therapeutic intervention for patients with urothelial carcinoma of the upper tract (UTUC). Although the role of lymphadenectomy in these tumors has not yet been clarified, recent evidence has shown that in patients with locally advanced tumors, it improves staging and consequently could help in selecting patients for adjuvant chemotherapy. UTUC and bladder carcinomas, are considered to be relatively chemosensitive. In fact, most of the data regarding the clinical efficacy of chemotherapy in the neoadjuvant and adjuvant settings are based on outcomes from the treatment of bladder UC. Contrary to what has been demonstrated for bladder cancer, there have been no convincing reported effects of neoadjuvant chemotherapy for UTUCs. Adjuvant chemotherapy achieves a remission rate of up to 50% but has minimal impact on survival.
    Systemic recurrences are common in this disease, however, and it is therefore reasonable to consider perioperative chemotherapy in an effort to decrease a patient’s risk of recurrence. The aim of this session is to discuss modern outcomes after radical nephroureterectomy and perioperative chemotherapy.

  • Poster viewing of 20 minutes. Presentations will take place on stage. Standard presentations are 2 minutes in length, followed by 2 minutes for discussion. Extended presentations (*) are 3 minutes in length, followed by 3 minutes for discussion.
* 1158
Effectiveness of adjuvant chemotherapy after radical nephroureterectomy for locally advanced and/or positive regional lymph node upper tract urothelial carcinoma

By: Seisen T.1, Krasnow R.1, Bellmunt J.2, Rouprêt M.3, Leow J.1, Lipsitz S.1, Vetterlein M.1, Preston M.1, Hanna N.1, Kibel A.1, Sun M.1, Choueiri T.2, Trinh Q-D.1, Chang S.L.1

Institutes: 1Brigham and Women Hospital, Dept. of Urology, Boston, United States of America, 2Dana Farber Cancer Institute, Dept. of Genito Urinary Medical Oncology, Boston, United States of America, 3Hôpitaux Universitaires La Pitié-Salpêtrière, Dept. of Urology, Paris, France

1159
Integrated comprehensive genomic characterization of upper tract urothelial carcinoma (UTUC)

By: Moss T.3, Qi Y.3, Xi L.2, Peng B.3, Mosqueda M.5, Guo C.6, Ittman M.4, Wheeler D.2, Matin S.7, Lerner S.1

Institutes: 1Baylor College of Medicine, Scott Dept. of Urology, Houston, United States of America, 2Baylor College of Medicine, Human Genome Sequencing Center, Houston, United States of America, 3MD Anderson Cancer Center, Dept. of Bioinformatics and Computational Biology, Houston, United States of America, 4Baylor College of Medicine, Dept. of Pathology, Houston, United States of America, 5MD Anderson Cancer Center, Institute for Personalized Cancer Therapy, Houston, United States of America, 6MD Anderson Cancer Center, Dept. of Pathology, Houston, United States of America, 7MD Anderson Cancer Center, Dept. of Urology, Houston, United States of America

1160
Perioperative chemotherapy does not improve disease free survival in upper tract urothelial carcinoma: A population based analysis

By: Goldberg H., Klaassen Z., Chandrasekar T., Hamilton R., Kulkarni G., Fleshner N.

Institutes: Princess Margaret Hospital, Division of Urology, Department of Surgical Oncology, Toronto, Canada

1161
Association of PD-L1 expression with cancer-specific survival in upper tract urothelial carcinoma

By: Zhang B.1, Yu W.1, Feng X-R.2, Zhao Z.1, Fan Y.1, Meng Y-S.1, Hu S.1, Cui Y.1, He Q.1, Zhang H.3, Li D.3, Zhou L-Q.1, He Z-S.1, Jin J.1, Han W-K.1

Institutes: 1Peking University First Hospital, Dept. of Urology, Beijing, China, 2Peking University First Hospital, Dept. of Geriatrics, Beijing, China, 3Peking University First Hospital, Dept. of Pathology, Beijing, China

1162
Comparing oncological outcomes of laparoscopic versus open nephroureterectomy for the treatment of upper tract urothelial carcinoma: A propensity match analysis

By: Moschini M.1, Seisen T.2, Roupret M.2, Foerster B.1, Abufaraj M.1, Colin P.3, De La Taille A.4, Peyronnet B.5, Bensalah K.5, Herout R.6, Wirth M.P.6, Novotny V.6, Chlosta P.7, Bianchi M.8, Briganti A.9, Romeo G.10, Simone G.10, Gallucci M.10, Matsumoto K.11, Karakiewicz P.12, Shariat S.1

Institutes: 1Medical University of Vienna, Dept. of Urology, Vienna, Austria, 2Pitié-Salpétrière, Assistance-Publique Hôpitaux De Paris, Dept. of Urology, Paris, France, 3Hôpital Privé De La Louvière, Générale De Santé, Dept. of Urology, Lille, France, 4Hopital Mondor, Dept. of Urology, Creteil, France, 5CHU Rennes, Dept. of Urology, Rennes, France, 6Technische Universität Dresden, Dept. of Urology, Dresden, Germany, 7Jagiellonian University, Dept. of Urology, Krakow, Germany, 8Urological Research Institute, Vita-Salute University, San Raffaele Scientific, Dept. of Urology, Milan, Italy, 9Urological Research Institute, Vita-Salute University, San Raffaele Scientifi, Dept. of Urology, Milan, Italy, 10“Regina Elena” National Cancer Institute, Dept. of Urology, Rome, Italy, 11Kitasato University School of Medicine, Dept. of Urology, Kanagawa, Japan, 12University of Montreal, Dept. of Urology, Montreal, Canada

1163
Prognostic impact of primary tumor location in advanced urothelial tract cancer (UCC); a pooled analysis of EORTC 30924, 30986, and 30987 trials

By: Moschini M.2, Shariat S.3, Roupret M.4, De Santis M.5, Bellmunt J.6, Sternberg C.7, Tombal B.1, Collette L.8

Institutes: 1Cliniques Universitaires Saint-Luc, Dept. of Urology, Brussels, Belgium, 2Vita Salute San Raffaele, Dept. of Urology, Milan, Italy, 3Medical University Vienna, Dept. of Urology, Vienna, Austria, 4Hôpital Pitié-Salpétrière, Dept. of Urology, Paris, France, 5University of Warwick, Cancer Research Center, Coventry, United Kingdom, 6Dana-Farber Cancer Institute, Dept. of Medical Oncology, Havard, United States of America, 7San Camillo and Forlanini Hospitals, Dept.of Medical Oncology, Rome, Italy, 8EORTC, Dept. of Statistics, Brussels, Belgium

* 1164
Trends of lymphadenectomy in upper tract urothelial carcinoma patients treated with radical nephroureterectomy: The impact of surgical technique

By: Moschini M.1, Seisen T.2, Roupret M.2, Colin P.3, De La Taille A.4, Peyronnet B.5, Bensalah K.5, Foester B.1, Herout R.6, Abufaraj M.1, Wirth M.P.6, Novotny V.6, Chlosta P.7, Bandini M.8, Briganti A.8, Simone G.9, Gallucci M.9, Romeo G.9, Matsumoto K.10, Karakiewicz P.11, Shariat S.1

Institutes: 1Medical University of Vienna, Dept. of Urology, Vienna, Austria, 2Pitié-Salpétrière, Assistance-Publique Hôpitaux, Dept. of Urology, Paris, France, 3Hôpital Privé De La Louvière, Dept. of Urology, Lille, France, 4Hopital Mondor, Dept. of Urology, Creteil, France, 5CHU Rennes, Dept. of Urology, Rennes, France, 6Technische Universität Dresden, Dept. of Urology, Dresden, Germany, 7Jagiellonian University, Dept. of Urology, Krakow, Poland, 8Vita-Salute University, San Raffaele Scientifi, Dept. of Urology, Milan, Italy, 9Regina Elena National Cancer Institute, Dept. of Urology, Rome, Italy, 10Kitasato University School of Medicine, Dept. of Urology, Kanagawa, Japan, 11University of Montrea, Dept. of Urology, Montreal, Canada

1165
Clinical benefit of platinum-based neoadjuvant chemotherapy for locally advanced upper tract urothelial carcinoma

By: Hatakeyama S., Hosogoe S., Kusaka A., Hamano I., Imai A., Yoneyama T., Hashimoto Y., Koie T., Ohyama C.

Institutes: Hirosaki University Graduate School of Medicine, Dept. of Urology, Hirosaki, Japan

1166
Significance of buttyrylcholinesterase before chemotherapy as an independent predictor of over-all survival in patients with advanced upper-tract urothelial cancer

By: Yoneyama T., Oikawa M., Hagiwara K., Toshikazu T., Narita T., Imanishi K., Yoneyama T., Mori K., Imai A., Hatakeyama S., Hashimoto Y., Koie T., Ohyama C.

Institutes: Hirosaki University Graduate School of Medicine, Dept. of Urology, Hirosaki, Japan

1167
1000 retroperitoneoscopic procedures of the upper urinary tract: Analysis of complications

By: Klap J., Cholley I., Masson-Lecomte A., Defontaines J., Vordos D., Hoznek A., Yiou R., Abbou C-C., De La Taille A., Salomon L.

Institutes: CHU Henri Mondor, Dept. of Urology, Créteil, France

1168
Comparative effectiveness of different surgical approaches for nephro-uretrectomy for the treatment of upper tract urothelial carcinoma

By: Hanna N., Ingham M., Seisen T., Chang S.

Institutes: Brigham and Women’s Hospital, Harvard Medical School, Dept. of Urology, Boston, Canada

1170
Ability of early ureteral ligation to prevent intravesical recurrence after radical nephroureterectomy for upper urinary tract urothelial carcinoma: A prospective single-arm multicenter clinical trial

By: Yamashita S.1, Ito A.1, Mitsuzuka M.1, Aizawa A.2, Ioritani N.2, Ishidoya S.3, Ikeda Y.4, Numahata K.5, Orikasa K.6, Tochigi T.7, Soma F.8, Namima T.9, Saito H.10, Sato M.11, Katoh S.12, Ota S.13, Kyan A.14, Takeda A.15, Kaiho Y.1, Arai Y.1

Institutes: 1Tohoku University Graduate School Of Medicine, Dept. of Urology, Sendai, Japan, 2Japan Community Health Care Organization Sendai Hospital, Dept. of Urology, Sendai, Japan, 3Sendai City Hospital, Dept. of Urology, Sendai, Japan, 4Osaki Citizen Hospital, Dept. of Urology, Osaki, Japan, 5Yamagata Prefectural Central Hospital, Dept. of Urology, Yamagata, Japan, 6Kesennuma City Hospital, Dept. of Urology, Kesennuma, Japan, 7Miyagi Cancer Center, Dept. of Urology, Natori, Japan, 8Hachinohe City Hospital, Dept. of Urology, Hachinohe, Japan, 9Tohoku Rosai Hospital, Dept. of Urology, Sendai, Japan, 10Sendai Medical Center, Dept. of Urology, Sendai, Japan, 11Senenrifu Hospital, Dept. of Urology, Rifu, Japan, 12Ogachi Central Hospital, Dept. of Urology, Yuzawa, Japan, 13Japanese Red Cross Sendai Hospital, Dept. of Urology, Sendai, Japan, 14Shirakawa Kosei General Hospital, Dept. of Urology, Shirakawa, Japan, 15Iwate Prefectural Iwai Hospital, Dept. of Urology, Ichinoseki, Japan

1171
Robotic radical nephroureterectomy is associated with poorer oncological outcomes than open and laparoscopic radical nephroureterectomy

By: Peyronnet B.1, Brichart N.2, Bruyere F.3, Seisen T.4, Alimi Q.1, Vanalderwerelt V.3, Rammal A.2, Mathieu R.1, Tondut L.1, Pradere B.3, Colin P.5, Verhoest G.1, Roupret M.6, Bensalah K.1

Institutes: 1CHU Rennes, Dept. of Urology, Rennes, France, 2CH Orleans, Dept. of Urology, Orleans, France, 3CHU Tours, Dept. of Urology, Tours, France, 4PItié Salpétrière Hospital, Dept. of Urology, Paris, France, 5CHU Lille, Dept. of Urology, Lille, France, 6Pitié Salpétrière Hospital, Dept. of Urology, Paris, France